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KMID : 1134820150440020182
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 2 p.182 ~ p.190
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Immunological Synergistic Effects of Combined Treatment with Herbal Preparation (HemoHIM) and Red Ginseng Extracts
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Byun Myung-Woo
Byun Eui-Hong
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Abstract
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This present study demonstrates the immunological synergistic effects of herbal preparation (HemoHIM) and red ginseng powder granule in various immune cell models (bone marrow-derived macrophages, dendritic cells, and mouse splenocytes) from mice. Both herbal preparation and red ginseng extracts were treated to bone-marrow derived macrophages, dendritic cells, and mouse splenocytes, and there was no cytotoxicity at a dose below 200 μg/mL. Cell proliferation and cytokine [tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-12] production tested in bone marrow-derived macrophages and dendritic cells significantly increased upon combined treatment. Cell surface marker (CD 80/86, MHC class Ⅰ/Ⅱ)-mediated immune cell activation was highly elevated by combined treatment. For cytokine production in splenocytes, combined treatment significantly increased production of Th 1 type cytokines [IL-2 and interferon (IFN)-γ] but not Th 2 type cytokines (IL-4 and IL-10). Therefore, combined treatment with HemoHIM and red ginseng extracts is an effective method to establish powerful immunological synergy in immune cells.
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KEYWORD
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HemoHIM, red ginseng extracts, macrophage, dendritic cell, splenocyte
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